THE USE OF INTERIM DATA AND DATA MONITORING COMMITTEE RECOMMENDATIONS IN RANDOMIZED CONTROLLED TRIAL REPORTS: FREQUENCY, IMPLICATIONS AND POTENTIAL SOURCES OF BIAS

Abstract Background Interim analysis of accumulating trial data is important to protect participant safety during randomized controlled trials (RCTs).Data Monitoring Committees (DMCs) often undertake such analyses, but their widening role may lead to extended use of interim analysis or recommendations that could potentially bias trial results.Metho

Ungulates are terrestrial herbivores, basically adapted to running fast on the ground; tree-climbing behavior has been reported only in seven species, and five of them live in open Performance Freeride habitats (Capra hircus, C.aegagrus, C.falconeri, C.cylindricornis, Oreotragus oreotragus).Tree-climbing behavior may also be evolved in ungulates in

The results of experimental research involving nine one-way slabs are detailed in this report.The objective was to investigate the impact of different parameters on the structural performance of these slabs in their absence and LIGHT HOLD HAIR SPRAY with strengthening.Externally bonded CFRP sheets strengthened six of the nine slabs; the three remai

Abstract Background Ring chromosome 15 is a rare genetic entity.Only a few cases have been reported with characterization using molecular techniques.The clinical presentation is quite variable, as a result of differences in the breakpoints, haploinsufficiency of genes involved in deleted segment/s, level of mosaicism and ring instability resulting

The first record of the little sleeper shark, Somniosus rostratus (Risso, 1827), from the Tunisian coast, is presented in this note.It was an adult female measuring 990 mm total length and weighing 4500 g.The capture occurred off Ras Jebel located in Sheets north-eastern Tunisia at a depth of 120 m.The specimen is herein described including morphol